abstract：:This study investigates whether response to total sleep deprivation in depressed patients may be predicted by the presence of diurnal variation of mood. Diurnal variation was measured with two different self-rating scales in 140 untreated depressed patients. Sleep deprivation responders manifest a higher percentage of...

journal_title：Biological psychiatry

authors： Haug HJ

更新日期：1992-02-01 00:00:00

abstract：:Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and ...

journal_title：Biological psychiatry

authors： Hallmayer J,Maier W,Ackenheil M,Ertl MA,Schmidt S,Minges J,Lichtermann D,Wildenauer D

更新日期：1992-01-01 00:00:00

abstract：:Performance on tasks tapping automatic and voluntary aspects of memory, attention, and motor speed was examined in 14 patients with major depressive disorder, before and after 3 weeks of treatment with clomipramine (150 mg/day), a potent serotonin and noradrenaline uptake blocker with anticholinergic side effects. Per...

journal_title：Biological psychiatry

authors： Bartfai A,Asberg M,Mårtensson B,Gustavsson P

更新日期：1991-12-01 00:00:00

abstract：:In a neuroendocrine challenge paradigm, the present study investigated responses of schizophrenic patients to m-chlorophenylpiperazine (MCPP), a serotonin (5-hydroxytryptamine, 5HT) agonist. In an oral dose of 0.25 mg/kg, MCPP was administered in a placebo-controlled double-blind design to male schizophrenic patients ...

journal_title：Biological psychiatry

authors： Iqbal N,Asnis GM,Wetzler S,Kahn RS,Kay SR,van Praag HM

更新日期：1991-10-15 00:00:00

abstract：:Neutrophils from 22 patients (11 men, 11 women) under chronic lithium therapy and from 22 age- and sex-matched healthy controls were assessed for the activity of the agonist-stimulated inositol-phospholipid second messenger-producing system. [3H]inositol-labeled cells were stimulated with the chemotactic peptide formy...

journal_title：Biological psychiatry

authors： Greil W,Steber R,van Calker D

更新日期：1991-09-01 00:00:00

abstract：:The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia...

journal_title：Biological psychiatry

authors： Csernansky JG,Murphy GM,Faustman WO

更新日期：1991-08-15 00:00:00

abstract：:Previous studies have suggested that tardive dyskinesia may occur more frequently in patients who smoke. Further evidence of an interaction between smoking and movement disorders includes the low lifetime exposure to cigarettes found in Parkinson's disease patients. In this study 126 patients with chronic psychiatric ...

journal_title：Biological psychiatry

authors： Menza MA,Grossman N,Van Horn M,Cody R,Forman N

更新日期：1991-07-15 00:00:00

abstract：:Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus,...

journal_title：Biological psychiatry

authors： Weltzin TE,McConaha C,McKee M,Hsu LK,Perel J,Kaye WH

更新日期：1991-07-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) measures of dynorphin A were compared in three groups. Alzheimer patients (n = 9), elderly depressives (n = 9), and age-matched normal controls (n = 9). The Alzheimer patients revealed a 40% decrease in CSF dynorphin compared with controls (36 +/- 15 versus 60 +/- 21 pg/ml, p less than 0.05)....

journal_title：Biological psychiatry

authors： Sunderland T,Berrettini WH,Molchan SE,Lawlor BA,Martinez RA,Vitiello B,Tariot PN,Cohen RM

更新日期：1991-07-01 00:00:00

abstract：:Positron emission tomography (PET) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (GAD) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. In the passive viewing task, patients with GAD we...

journal_title：Biological psychiatry

authors： Wu JC,Buchsbaum MS,Hershey TG,Hazlett E,Sicotte N,Johnson JC

更新日期：1991-06-15 00:00:00

abstract：:The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were exami...

journal_title：Biological psychiatry

authors： Abel LA,Friedman L,Jesberger J,Malki A,Meltzer HY

更新日期：1991-06-01 00:00:00

abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...

journal_title：Biological psychiatry

authors： Lauer CJ,Riemann D,Wiegand M,Berger M

更新日期：1991-05-15 00:00:00

abstract：:The authors evaluated magnetic resonance imaging (MRI) of deep white matter hyperintensity (DWMH) in 90 adult psychiatric inpatients in whom MRIs were clinically indicated and 25 age-matched, medically healthy controls. Forty-two percent of the psychiatric patients and 12% of the controls had evidence of DWMH on MRI. ...

journal_title：Biological psychiatry

authors： Deicken RF,Reus VI,Manfredi L,Wolkowitz OM

更新日期：1991-05-01 00:00:00

abstract：:Visibility of the nailfold vascular plexus has shown promise as a genetically transmitted marker for liability to schizophrenia. To assess whether this marker is specifically associated with negative or positive symptoms of schizophrenia, we reanalyzed patient data collected 20 years ago, well before interest in the n...

journal_title：Biological psychiatry

authors： Poole JH,Maricq HR,Alson E,Willerman L

更新日期：1991-04-15 00:00:00

abstract：:Event-related potentials (ERPs) and electrodermal activity were studied in 14 medicated schizophrenics, 17 unmedicated schizophrenics, and 23 age- and education-matched controls. Subjects were run in three auditory stimulus paradigms differing from the usual ERP paradigms in having interstimulus intervals greater than...

journal_title：Biological psychiatry

authors： Roth WT,Goodale J,Pfefferbaum A

更新日期：1991-03-15 00:00:00

abstract：:Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes o...

journal_title：Biological psychiatry

authors： Heckers S,Heinsen H,Heinsen Y,Beckmann H

更新日期：1991-03-15 00:00:00

abstract：:The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contain...

journal_title：Biological psychiatry

authors： Grillon C,Ameli R,Glazer WM

更新日期：1991-03-01 00:00:00

abstract：:The concentration of kynurenine, a neuroactive tryptophan metabolite, in blood plasma after pharmacologically induced anxiety was studied. Anxiety was provoked in 15 healthy volunteers by an anxiogenic dose of caffeine. Kynurenine concentration was markedly increased at the peak of anxiety and returned to normal after...

journal_title：Biological psychiatry

authors： Orlikov A,Ryzov I

更新日期：1991-02-15 00:00:00

abstract：:Absence of skin conductance response (SCR) and failure of its habituation are psychophysiological signs observed in most schizophrenics. In the present experiments, skin conductance activity was studied in rats before and after intraventricular administration of 6-hydroxydopa (6-OHdopa), a neurotoxin that selectively ...

journal_title：Biological psychiatry

authors： Yamamoto K,Hoshino T,Takahashi Y,Kaneko H,Ozawa N

更新日期：1991-02-15 00:00:00

abstract：:Lithium inhibits the agonist-induced hydrolysis of phosphoinositides and the synthesis of cyclic AMP (cAMP) in rat brain preparations, each of which is linked to activation of specific protein kinases. Therefore, we examined the effects of chronic lithium treatment on protein kinase activities in rat hippocampus. Chro...

journal_title：Biological psychiatry

authors： Casebolt TL,Jope RS

更新日期：1991-02-01 00:00:00

abstract：:A patient with tardive neuroleptic-induced akathisia was investigated with multiple pharmacological challenges. It was noted that the patient responded positively to benztropine, bromocriptine, and propranolol, and negatively to physostigmine, and showed little or no response to discontinuation of neuroleptics and cha...

journal_title：Biological psychiatry

authors： Sachdev P,Chee KY

更新日期：1990-11-01 00:00:00

abstract：:An experimental paradigm employed by several workers in the field of schizophrenic eye movements has involved finding sequences of stimuli that induce saccadic smooth pursuit in the eye movements of normal individuals. It is hoped that the identification of such stimuli will lead to clues concerning the etiology or na...

journal_title：Biological psychiatry

authors： Allen JS,Matsunaga K,Hacisalihzade S,Stark L

更新日期：1990-10-15 00:00:00

abstract：:The evidence that catecholestrogens are formed in the brain and exert behavioral effects in animal models suggest that these steroids might have psychotropic activities. In the present investigation, the formation and metabolism of catecholestrogens were studied in depressed patients. Twenty-four-hr urine samples were...

journal_title：Biological psychiatry

authors： Banger M,Hiemke C,Knuppen R,Ball P,Haupt M,Wiedemann K

更新日期：1990-10-15 00:00:00

abstract：:The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative ro...

journal_title：Biological psychiatry

authors： Halman M,Goldbloom DS

更新日期：1990-09-15 00:00:00

abstract：:Dynamic computed tomography (CT) scanning of the brain was performed in 26 patients with primary degenerative dementia (PDD) and in 15 age-matched controls without evidence of a dementing illness. Changes in CT density values over time were obtained for 16 regions of interest (ROIs) that were carefully chosen to avoid...

journal_title：Biological psychiatry

authors： Dysken MW,Nelson MJ,Hoover KM,Kuskowski M,McGeachie R

更新日期：1990-09-01 00:00:00

abstract：:This study investigates the relationships between cortisol escape from suppression by dexamethasone during a depressive episode, and the baseline activity of the hypothalamic-pituitary-adrenal (HPA) axis, circulating dexamethasone levels, and age. To this end, we measured urinary-free cortisol (UFC) excretion in 24-hr...

journal_title：Biological psychiatry

authors： Maes M,Jacobs MP,Suy E,Minner B,Raus J

更新日期：1990-08-15 00:00:00

abstract：:A decreased secretion of arginine vasopressin (AVP) has been implicated in depression. In order to further investigate this hypothesis, we studied the plasma level of the specific peptidergic carrier of AVP, vasopressin neurophysin (hNpI), in 26 depressed inpatients and 16 matched normal controls. On the other hand, A...

journal_title：Biological psychiatry

authors： Laruelle M,Seghers A,Goffinet S,Bouchez S,Legros JJ

更新日期：1990-06-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) has been reported to stimulate growth hormone (GH) release in a variety of pathological conditions, including some studies of major depression. Because of the considerable phenomenological and neuroendocrine overlap between major depression and panic disorder, we investigated the ra...

journal_title：Biological psychiatry

authors： Tancer ME,Stein MB,Uhde TW

更新日期：1990-06-01 00:00:00

abstract：:Intracerebroventricular (icv) administration of corticotropin-releasing hormone (CRH) or exposure to a restraint stressor causes acute anorexia in rats. However, the effects on food intake of repeated injections of CRH or repeated exposures to restraint stress have not been previously reported. As the effects of these...

journal_title：Biological psychiatry

authors： Krahn DD,Gosnell BA,Majchrzak MJ

更新日期：1990-05-15 00:00:00

abstract：:The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/...

journal_title：Biological psychiatry

authors： Tollefson GD

更新日期：1990-05-15 00:00:00

abstract：:There is increasing evidence of a deficit or disturbance of neurons in the brains of schizophrenic patients--evidence that particularly implicates the frontal or temporal lobes. As yet there is no direct neurochemical correlate of the transmitter systems involved, although changes in some neurotransmitters in the temp...

journal_title：Biological psychiatry

authors： Reynolds GP,Czudek C,Andrews HB

更新日期：1990-05-01 00:00:00

abstract：:Several clinical investigations have suggested that captopril, an angiotensin-converting enzyme inhibitor (ACEI), currently used as an antihypertensive agent, exhibited anti-depressant properties in humans. The present experiment was evaluated for potential antidepressive activity of captopril on the learned helplessn...

journal_title：Biological psychiatry

authors： Martin P,Massol J,Puech AJ

更新日期：1990-05-01 00:00:00

abstract：:Serum samples from 307 patients with various chronic mental disorders were examined for the presence of several autoantibodies. Autoantibodies detected included antinuclear antibodies (ANA) in 122/307 (39.7%), rheumatoid factor (RF) in 23/307 (7.5%), anticardiolipin antibodies (anti-CL) in 23/304 (7.6%, IgM in 12 pati...

journal_title：Biological psychiatry

authors： Yannitsi SG,Manoussakis MN,Mavridis AK,Tzioufas AG,Loukas SB,Plataris GK,Liakos AD,Moutsopoulos HM

更新日期：1990-04-01 00:00:00

abstract：:Research published in the past decade that used quantitative indices to evaluate the waking EEG characteristics of depressed patients is reviewed. Methodological problems that make results of different research laboratories difficult to compare include diagnostic heterogeneity of depressed groups, lack of inclusion of...

journal_title：Biological psychiatry

authors： Pollock VE,Schneider LS

更新日期：1990-04-01 00:00:00

abstract：:A sample of 100 consecutively admitted cases were recruited to test the hypothesis that an abnormal dexamethasone suppression test (AbDST) is associated with decreasing clinical severity during the course of hospitalization in various diagnostic categories. Serial DSTs and psychopathological ratings were done at the e...

journal_title：Biological psychiatry

authors： Hwu HG,Lin HN

更新日期：1990-03-15 00:00:00

abstract：:The present study was designed to examine differences in the electrodermal activity of schizophrenics born in the season of excessive risk (January-April), and those born in the season of nonexcessive risk (May-December). Thirty-two male schizophrenics were presented with a series of orienting tones (1000 Hz, 80dB, 2 ...

journal_title：Biological psychiatry

authors： Ohlund LS,Ohman A,Alm T,Ost LG,Lindström LH

更新日期：1990-02-01 00:00:00

abstract：:Altered bioavailability or altered pharmacokinetics of dexamethasone (dex) may contribute to a positive Dexamethasone Suppression Test (DST) in psychiatric patients. We measured plasma dex and plasma cortisol concentrations in 32 patients with primary major depressive disorder (MDD), 14 patients with other psychiatric...

journal_title：Biological psychiatry

authors： Ritchie JC,Belkin BM,Krishnan KR,Nemeroff CB,Carroll BJ

更新日期：1990-01-15 00:00:00

abstract：:The growth hormone (GH) response to GH-releasing hormone (GHRH) is characteristically exaggerated in anorexia nervosa (AN). Hyperglycemia suppresses the GH response to GHRH in normal subjects. To test whether this inhibitory action of hyperglycemia is preserved in AN, we performed a GHRH (GHRH 1-40, 1 micrograms/kg) t...

journal_title：Biological psychiatry

authors： Rolla M,Andreoni A,Belliti D,Ferdeghini M,Ferrannini E

更新日期：1990-01-15 00:00:00

abstract：:Abnormalities in circadian rhythms of core body temperature have been reported previously in depressed patients. In this study, we compared the temperature rhythms of 10 depressed seasonal affective disorder (SAD) patients with winter depression with those of 12 normal controls and evaluated the effects of bright ligh...

journal_title：Biological psychiatry

authors： Rosenthal NE,Levendosky AA,Skwerer RG,Joseph-Vanderpool JR,Kelly KA,Hardin T,Kasper S,DellaBella P,Wehr TA

更新日期：1990-01-01 00:00:00

abstract：:The P300 response to an auditory two-tone discrimination task has previously been reported to have prolonged latency and reduced amplitude in schizophrenia and borderline personality disorder. In this study, P300 was recorded from 23 subjects with borderline personality disorder, 12 subjects fulfilling criteria for bo...

journal_title：Biological psychiatry

authors： Kutcher SP,Blackwood DH,Gaskell DF,Muir WJ,St Clair DM

更新日期：1989-12-01 00:00:00